Nuclear Spin Chemistry for Next-Generation Magnetic Resonance
Dr. Danila Barskiy (Johannes Gutenberg Universität)

Nuclear magnetic resonance (NMR) is undergoing renaissance: the advent of hyperpolarization techniques allows enhancing weak nuclear signals by orders of magnitude, making possible measurements which were previously considered impractical, e.g., monitoring metabolism in vivo. Since large magnetic fields are no longer necessary to generate large nuclear magnetization, non-conventional signal detection approaches are now being considered as an alternative to conventional, inductive schemes. In my talk, I will focus on our recent work demonstrating that parahydrogen-based spin chemistry can be used for generating hyperpolarized analytes for low (<1 tesla) and ultralow-field (<100 nT) NMR. The presented method is applicable to a wide range of small molecules possessing exchangeable protons and have potential applications for chemical analysis and measuring NMR spectra from natural extracts and biological fluids using portable spectroscopic tools.